Intrinsic Noise Initiates Cell Migration

Stochastic initiation of pressure-driven cell migration.

Blebs are cellular protrusions that appear as smooth spherical expansions of the membrane formed when it separates from the underlying actin cortex, driven by hydrostatic pressure generated in the cytoplasm by the contractile actomyosin cortex. In this project, we propose a model that the blebs are persistently developed by intrinsic noise, which comes from the assembly and turnover of the discrete cortical protein units. The dynamical system escapes the basin of attraction by accumulating the noise, as illustrated in the figure.

MJ Munoz-Lopez, H Kim, and Y Mori, “A Reduced 1D Stochastic Model of Bleb-driven Cell Migration,” (2022) Biophysical Journal. [DOI]

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